Manual Animal Models of Molecular Pathology (Progress in Molecular Biology and Translational Science)

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Progress in molecular biology and translational science. Animal models of human disease. Preface.

Contact Info. Service Needed. Mouse Background Needed. Additional Information. Please add a detailed description of your project goals. If you require KO mouse generation, please be sure to indicate the gene, and whether you require a global KO or a conditional KO and the mouse background required. Please also indicate if you require a tag or reporter.

1. Introduction

If you require a targeted knock-in mouse model please indicate the gene details and any information you may know about the promoter. If you require a transgenic mouse, such as for over expressing a gene, humanizing a mouse or a Cre-expressing mouse, etc. If you require genotyping, please indicate the type of genotyping required and the tissues to be genotyped mouse tissue, ES cells, DNA etc.

If you require mouse breeding, please outline the details of existing mouse line if any and the goals of your project. If you require phenotyping, please provide as much information as possible on your project goals. If you are attempting to replicate results or tests in a particular publication, please reference the journal article.

We will contact you to discuss your project in detail and provide a full quote and project proposal before you are obligated to provide any payment information. Add files. News Events Featured Services. Our team of experienced scientists and technical staff can help you select the best approach for your research project and guide you through your project's development. Rat models are now available. Let us know how we can help you and one of our customer service specialists will assist as soon as they can.

What services are you interested in? Export Mice or Materials Other Please explain. Can't find the mouse you want? No one has it? Well, we're here to help! Just let us know the gene name, whether you want a transgenic or knockout, and the genetic background, and we'll prepare a plan for making the mouse you want. So go ahead, make my day, and tell us Make My Mouse!


Notice: Having problem submit the form? Mutation Type. Looking for a specific mutant mouse? Just tell us the gene name, and whether you want a knockout or transgenic, and we will search the world for it. If it exists somewhere already, we will find it and let you know in less than 48 hours. Fill in this form, hit the submit button, and that's it! Her research on nuclear reprogramming and demonstrating the plasticity of cell fate using cell fusion is well known and her laboratory has also pioneered the design of biomaterials to mimic the in vivo microenvironment and direct stem cell fate.

Current findings are leading to more efficient iPS generation, cell based therapies by dedifferentiation a la newts, and discovery of novel molecules and therapies.

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Current Research and Scholarly Interests Our lab uses chemical, biochemical, and cell biological methods to study protease function in human disease. Projects include: 1 Design and synthesis of novel chemical probes for serine and cysteine hydrolases. Brown, currently an emeritus professor, is CEO and founder of Impossible Foods, a company dedicated to replacing the world's most destructive technology - the use of animals to transform plant biomass into meat, fish and dairy foods - by developing a new and better way to produce the world's most delicious, nutritious and affordable meats, fish and dairy foods directly from plants.

Visit impossiblefoods. Current Research and Scholarly Interests Our interests include: 1 The physiology and function of lymphocyte homing in local and systemic immunity; 2 Biochemical and genetic studies of molecules that direct leukocyte recruitment; 3 Chemotactic mechanisms and receptors in vascular and immune biology; 4 Vascular control of normal and pathologic inflammation and immunity; 5 Systems biology of immune cell trafficking and programming in tumor immunity.

Current Research and Scholarly Interests My lab is developing innovative gene and stem cell therapies for genetic diseases, with a focus on gene therapy and regenerative medicine. We have created novel methods for inserting therapeutic genes into the chromosomes at specific places by using homologous recombination and recombinase enzymes. We are working on 3 forms of muscular dystrophy. We created induced pluripotent stem cells from patient fibroblasts, added therapeutic genes, differentiated, and engrafted the cells.

Current Research and Scholarly Interests Our laboratory combines synthetic chemistry and developmental biology to investigate the molecular events that regulate embryonic patterning, tissue regeneration, and tumorigenesis. We are currently using genetic and small-molecule approaches to study the molecular mechanisms of Hedgehog signaling, and we are developing chemical technologies to perturb and observe the genetic programs that underlie vertebrate development.

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Current Research and Scholarly Interests Contribution of T cells to immunocompetence and autoimmunity; how the immune system clears infection, avoids autoimmunity and how infection impacts on the development of immune responses. Current Research and Scholarly Interests Our group's primary objectives are: 1 Novel radioligand and radiotracer development. Although my personal research interests will be to discover and design of candidate probes that target molecular targets in the brain, our group focus will primarily be on cancer biology and gene therapy.

We will aim to design new radiolabeling techniques and methodologies that may have utility for future radiopharmaceutical development in our lab and the general radiochemistry community. Since we also have many interests with many Stanford faculty and outside collaborators, our efforts will also include the routine radiochemistry production of many existing radiotracers for human and non-human use.

Our routine clinical tracers will be synthesized in custom-made or commercial synthetic modules i. Comecer Dorothea to our imagers. Current Research and Scholarly Interests Genomic instability contributes to many diseases, but it also underlies many natural processes. The Cimprich lab is focused on understanding how mammalian cells maintain genomic stability in the context of DNA replication stress and DNA damage. We are interested in the molecular mechanisms underlying the cellular response to replication stress and DNA damage as well as the links between DNA damage and replication stress to human disease.

Current Research and Scholarly Interests Our group uses molecular biology, biochemistry, and cellular immunology to investigate the activation and effector function of T lymphocytes. Research in the laboratory is currently focused on three areas: granulysin, a lytic molecule expressed late days after T cell activation; identification of correlates of immunity in diseases such as tuberculosis; and tolerance.

The long term goal of this work is to develop new ways to treat human disease. Current Research and Scholarly Interests We develop and use the tools of molecular imaging to understand oncogenesis, reveal patterns of cell migration in immunosurveillance, monitor gene expression, visualize stem cell biology, and assess the distribution of pathogens in living animal models of human biology and disease. Biology doesn't occur in "a vacuum" or on coated plates--it occurs in the living body and that's were we look for biological patterns and responses to insult.

Current Research and Scholarly Interests Chromatin regulation and its roles in human cancer and the development of the nervous system. Engineering new methods for studying and controlling chromatin in living cells. Roles for short linear peptide motifs, or SLiMs, in substrate recognition, network evolution, and regulation of calcineurin activity are being studied. Current Research and Scholarly Interests We are using Saccharomyces cerevisiae and Human to conduct whole genome analysis projects.

The yeast genome sequence has approximately 6, genes. We have made a set of haploid and diploid strains 21, containing a complete deletion of each gene. In order to facilitate whole genome analysis each deletion is molecularly tagged with a unique mer DNA sequence. This sequence acts as a molecular bar code and makes it easy to identify the presence of each deletion. Current Research and Scholarly Interests My laboratory focuses on two main areas: 1 cancer stem cell biology and 2 novel biomarkers for identifying the presence of malignant cells diagnostic , predicting outcome prognostic , and predicting response to therapy predictive.

Areas of study include cancers of the lung, breast, and gastrointestinal system. Clinically I specialize in the treatment of lung cancer and applications of stereotactic ablative radiotherapy and perform both prospective and retrospective clinical studies. Current Research and Scholarly Interests I am highly interested in the interactions between the endocrine and immune systems in women.

Current clinical research interests lie in the field of autoimmune thyroid disease, especially thyroid autoimmunity in pregnancy. Current Research and Scholarly Interests Dendritic cells, macrophages, NK cells and T cells; functional proteins and genes; immunotherapeutic approaches to cancer, autoimmune disease, neurodegenerative disease and metabolic disease. Current Research and Scholarly Interests 1 Induction of immunotolerance 2 Rejection of liver and intestinal transplantation.

Fan is a physician scientist who studies how turning off oncogenes cancer genes can cause tumor regression in preclinical and clinical translational studies. Based on her findings, she has initiated clinical trials studying how targeted therapies affect cancer signals in kidney cancer and low grade lymphoma. In the laboratory, she uses new nanotechnology strategies for tumor diagnosis and treatment to define biomarkers for personalized therapy.

Current Research and Scholarly Interests My lab of molecular and cellular immunology is interested in research in the general field of T cell activation and autoimmunity. We have characterized a gene Deaf1 that plays a major role in peripheral tolerance in T1D. Using PBC gene expression, we have provisionally identified a signature of risk and progression in T1D.

Current Research and Scholarly Interests My laboratory investigates how oncogenes initiate and sustain tumorigenesis. I have developed model systems whereby I can conditionally activate oncogenes in normal human and mouse cells in tissue culture or in specific tissues of transgenic mice. In particular using the tetracycline regulatory system, I have generated a conditional model system for MYC-induced tumors.

I have shown that cancers caused by the conditional over-expression of the MYC proto-oncogene regress with its inactivation.

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Current Research and Scholarly Interests My lab has two main goals: to understand the regulation of mitosis and to understand the systems-level logic of simple signaling circuits. We often make use of Xenopus laevis oocytes, eggs, and cell-free extracts for both sorts of study.

We also carry out single-cell fluorescence imaging studies on mammalian cell lines. Our experimental work is complemented by computational and theoretical studies aimed at understanding the design principles and recurring themes of regulatory circuits. Current Research and Scholarly Interests Our research focus is define correlates of protection against hepatitis C virus and other viral pathogens. Detailed characterization of broadly neutralizing human or nonhuman primate monoclonal antibodies against these agents will create high-resolution, functional maps of linear and nonlinear epitopes comprising the major binding sites of both isolate-specific and broadly neutralizing antibodies for rational vaccine design.

Bio Dr. Franc has over 15 years of experience in clinical nuclear medicine with particular expertise in PET-CT. As a clinical leader, Dr. Franc has developed programs for the early adoption and implementation of nuclear-based imaging and therapeutic technologies including combined positron emission tomography PET and computed tomography CT combined PET-CT and combined single photon emission computed tomography and CT SPECT-CT for quantitative oncologic and cardiac applications.

Franc has experience in all aspects of PET radiopharmaceutical development, spanning the design of molecules, synthesis of radioligands, and use in animal and human imaging. He also has expertise in quantitative image analysis, development of novel post-processing image reconstruction methods, and the application of artificial intelligence in human diagnostics. Franc has implemented new radiopharmaceuticals in pre-clinical and clinical research PET imaging as well as for clinical PET with applications in cancer, infectious disease HIV , and autoimmune disease RA.

In addition to translational science and clinical research, Dr.

Animal Models in Drug Development

Franc has established himself in the area of health policy. His research, publications, and lectures in health policy focus on improving value of healthcare through decrease in variability and implementation of precision health techniques into the clinic. Current Research and Scholarly Interests Functional consequences and pathogenetic mechanisms of mutations and microdeletions in human neurogenetic syndromes and mouse models. Integration of genomic information into medical care.

Current Research and Scholarly Interests Structural and functional studies of transmembrane receptor interactions with their ligands in systems relevant to human health and disease - primarily in immunity, infection, and neurobiology. We study these problems using protein engineering, structural, biochemical, and combinatorial biology approaches. Current Research and Scholarly Interests Ion channels and signal transduction; patch clamp and fluorometric analysis; cell and molecular biology; cystic fibrosis gene therapy. Current Research and Scholarly Interests T cell homeostasis and function with age.

Current Research and Scholarly Interests We are interested in addressing questions in neuronal development and function by a combination of genetic, cell biological, biochemical and chemical approaches. The main focus of our lab is centered around two topics: 1 the interface of signaling and gene regulation in neuronal development, with a focus on calcineurin-NFAT signaling; 2 the development of small molecules, which interfere with protein-protein interactions underlying neurodegenerative diseases. Sigurdis Haraldsdottir, M. She received her medical degree and master's degree in medical sciences from the University of Iceland.

Her clinical and research focus is in gastrointestinal malignancies with a focus on mismatch repair deficient cancers, particularly colorectal cancer. She is conducting population-based research on Lynch syndrome - an inherited cancer syndrome, and recently completed a nation-wide study on Lynch syndrome in Iceland. She received her Ph. Her interests also focus on investigating colorectal cancer genomics, and their effect on outcomes and treatment implications. Karen G. Hirsch cares for critically ill patients with neurologic disorders in the intensive care unit and for patients with cerebrovascular disease in the inpatient stroke unit.

Hirsch's research focuses on novel imaging techniques such as functional brain imaging in patients with cardiac arrest and traumatic brain injury. She also studies methods of non-invasive measurement of cerebral blood flow, oxygenation, and cerebrovascular autoregulation and how these parameters might be targeted to improve outcome in patients with neurologic injury. In the outpatient clinic, she sees patients with head injury, stroke and other neurovascular diseases in addition to patients who have been discharged from the neurological intensive care unit. Current Research and Scholarly Interests Mechanism of genomic imprinting of insulin like growth factor-2 and other genes.

Long range chromatin interactions Role of histone modifications and DNA methylation in gene expression. Current Research and Scholarly Interests Research interests primarily involve medical diseases and transplantation pathology of the kidney and liver. Current Research and Scholarly Interests Our research program has several active projects: 1. Blinded clinical trials of efficacy are in progress. Lung inflammation and regeneration stem cells 3. Lung surfactant rheology and oxidative stress 4. She completed her internal medicine residency and rheumatology fellowship at UCSF, including a postdoc in the immunology lab of Dr.

Arthur Weiss. She is fascinated by the relationship between cancer and autoimmune diseases such as scleroderma and dermatomyositis, the paraneoplastic manifestations of various cancers, and the rheumatic complications of graft vs. She has spent time at Genentech, where she led several clinical trials in immunology.

Current Research and Scholarly Interests We work in epithelial tissue as a model system to study stem cell biology, cancer and new molecular therapeutics. Epithelia cover external and internal body surfaces and undergo constant self-renewal while responding to diverse environmental stimuli. Current Research and Scholarly Interests Our interests include 1 study of the effect of radiation on regulatory cell subpopulations and co-stimulatory molecules, 2 use of radiation as an immune modulator for optimization of transplant regimens, 3 the role of radiation in tumor vaccine strategies, 4 study of new radiosensitizers and radioprotectors, and 5 discovery of new targeted therapies for the treatment of solid tumors.

Current Research and Scholarly Interests Mechanisms and therapies for infection, cancer, autoimmunity and transplantation. Current Research and Scholarly Interests Our long term interest is to have a better understanding of the natural antithrombotic pathways and the pathophysiology of vascular thrombosis.

We have focused on thrombin, the key enzyme in the blood clotting cascade. Our goal is to develop new antithrombotic agents and devise new diagnostic tests for vascular thrombotic disorders. Research Interests: Immunology and molecular biology of lymphoid malignancy; molecular vaccines for cancer. Current Research and Scholarly Interests My laboratory is focused on defining cellular and molecular mechanisms that limit T cell responses to vaccines and pathogens during normal early postnatal development and in cases of inherited genetic immunodeficiencies.

We are also determinomg how these limitations in immunity can be overcome by using novel approaches for vaccine adjuvants for influenza vaccine and by using catalytically inactive Cas proteins for inducing endogenous gene expression. Current Research and Scholarly Interests We study molecular mechanisms of calcium signaling with a focus on store-operated CRAC channels and their essential roles in T cell development and function.

Currently we aim to define the molecular mechanism for CRAC channel activation and the means by which calcium signal dynamics mediate specific activation of transcription factors and T-cell genes during development. Current Research and Scholarly Interests Recent clinical studies, by us and others, have demonstrated that T cell based immunotherapy can eradicate cancers resistant to all other available therapies. Our program creates, develops and optimizes genetically engineered T cells to treat cancer.

We link the bench with the bedside, developing novel therapies for early phase testing in clinical trials, while simultaneously conducting intensive studies on clinical samples obtained from patients treated on immunotherapy trials. Current Research and Scholarly Interests The Mallick Lab is focused on using integrative, multi-omic approaches to model the processes that govern cellular dynamics and to use those models to discover cancer biomarkers and molecular mechanisms.

Current Research and Scholarly Interests Host-Pathogen interactions; EBV B cell lymphomas; pathways of immune evasion in the growth and survival of EBV B cell lymphomas; mechanisms of graft rejection and tolerance induction; stem cell and solid organ transplantation. Current Research and Scholarly Interests The structure of class II major histocompatibility complex molecules, their role in antigen presentation, and in the immune response in health and disease with emphasis on type 1 diabetes and rheumatoid arthritis; the role of lymphokines tumor necrosis factor alpha, lymphotoxin in autoimmunity.

We are using live single-cell microscopy approaches to understand the design principles of cell signaling circuits. Mammalian signaling processes have a unique logic due to the large number of signaling proteins, second messengers and chromatin modifiers involved in each decision process. We are particularly interested in understanding how cells make decisions to enter and exit the cell cycle and how they decide to polarize and move.

Current Research and Scholarly Interests Beverly Mitchell's research relates to the development of new therapies for hematologic malignancies, including leukemias and myelodsyplastic syndromes. She is interested in preclinical proof of principle studies on mechanisms inducing cell death and on metabolic targets involving nucleic acid biosynthesis in malignant cells.

She is also interested in the translation of these studies into clinical trials. Current Research and Scholarly Interests Two areas: 1. Using rationally-designed peptide inhibitors to study protein-protein interactions in cell signaling. Focus: protein kinase C in heart and large GTPases regulating mitochondrial dynamics in neurodegdenration. Using small molecules identified in a high throughput screens and synthetic chemistry as activators and inhibitors of aldehyde dehydrogenases, a family of detoxifying enzymes, and glucosephoshate dehydrogenase, in normal cells and in models of human diseases.

Current Research and Scholarly Interests Discovery, preclinical and clinical development of novel immunosuppressive molecules for prevention or treatment of immune or inflammatory or ischemic injury to cell and organ transplants and for suppression of autoimmune diseases and acute organ injuries including small molecule, monoclonal and biologic classes of therapeutics.

Current Research and Scholarly Interests Translation of discoveries in basic research into practical medical applications. Current Research and Scholarly Interests My research interests focus on the identification and characterization of markers of diagnostic and prognostic importance in hematolymphoid neoplasia. Current Research and Scholarly Interests I am a thoracic oncologist who cares for patients with non-small cell lung cancer, malignant mesothelioma, and other thoracic malignancies.

I design and conduct clinical trials of novel therapies in collaboration with other researchers and pharmaceutical companies. I also collaborate with other researchers on campus to apply emerging technologies to cancer therapy, for example, circulating tumor DNA detection. Additionally, in my role as the Cancer Center IT Medical Director, I coordinate projects relating to our use of the electronic health record to improve provider efficiency and facilitate patient care. Using advanced flow cytometric techniques such as Mass Cytometry, MIBI ion beam imaging , CODEX and computational biology approaches, we focus on understanding disease processes at the single cell level.

We have a strong interest in cancer immunotherapy and pathogen-host interactions. Current Research and Scholarly Interests Mechanims molecular and cellular of pulmonary hypertension, treatment of pulmonary hypertension, treatment of respiratory failure, treatment of septic shock, hemodynamic monitoring. Current Research and Scholarly Interests The laboratory develops and uses state of the art genomic methods to identify genetic factors affecting disease susceptibility, and to translate these findings into new treatments.

We have developed a more efficient method for performing mouse genetic analysis, which has been used to analyze the genetic basis for 16 different biomedical traits. We are developing novel methods, and have developed a novel experimental platform that replaces mouse liver with functioning human liver tissue.